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All About

Autologous Chondrocyte Implantation (ACI)

Wildlife

Symptoms

Patients with damage to the cartilage in a joint (articular cartilage damage) will experience

  • Inflammation - the area swells, becomes warmer than other parts of the body, and is tender, sore, and painful.
  • Stiffness.
  • Range limitation - as the damage progresses, the affected limb will not move so freely and easily.

 

Articular cartilage damage most commonly occurs in the knee, but the elbow, wrist, ankle, shoulder, and hip joint can also be affected.

In severe cases, a piece of cartilage can break off, and the joint can become locked. This can lead to hemarthrosis (bleeding in the joint); the area may become blotchy and have a bruised appearance.

Causes

Direct blow - if a joint receives a heavy impact, perhaps during a bad fall or an automobile accident, the cartilage may be damaged. Sportspeople have a higher risk of suffering from articular damage, especially those involved in high impact sports like American football, rugby, and wrestling.

 

Wear and tear - a joint that experiences a long period of stress can become damaged. Obese individuals are more likely to damage their knee over a 20-year period than a person of normal weight, simply because the body is under a much higher degree of physical stress. Inflammation, breakdown, and eventual loss of cartilage in the joints is known as osteoarthritis.

 

Lack of movement - the joints need to move regularly to remain healthy. Long periods of inactivity or immobility increase the risk of damage to the cartilage.

More about Treatment

Autologous chondrocyte implantation (ACI) is a relatively new, state-of-the-art procedure used to treat isolated full-thickness (down to bone) articular cartilage defects of the knee. It has been approved by the Food and Drug Administration for cartilage defects located at the end of the femur bone (thigh). ACI has also been performed for defects of the patella (knee cap) in addition to other joints of the body. Autologous chondrocyte implantation is a two-stage operative procedure.

 

 

FAQ on this Treatment

What are the steps of ACI?

The ACI is done in 2 steps:
Arthroscopic surgery: In this, the cartilage cells are collected and are made to multiply and increase in number in the lab. This takes about 6 weeks.
Implantation surgery: In this, the cultured cells are injected into the area of damage where they form new cartilage.

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